2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W040168
    Amino-PEG2-C2-acid 791028-27-8 99.72%
    Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG2-C2-acid
  • HY-140417
    t-Boc-Aminooxy-PEG4-NHS ester 2401831-99-8 99.90%
    t-Boc-Aminooxy-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-Aminooxy-PEG4-NHS ester
  • HY-W017755
    (R)-Azetidine-2-carboxylic acid 7729-30-8 99.86%
    (R)-Azetidine-2-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (R)-Azetidine-2-carboxylic acid is also a alkyl chain-based PROTAC linker that can be
    (R)-Azetidine-2-carboxylic acid
  • HY-130346
    DBCO-PEG4-DBCO 2182601-68-7
    DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-DBCO
  • HY-W190796A
    Mal-PEG3-NH2 TFA 2830214-77-0 99.07%
    Mal-PEG3-NH2 TFA is a linear heterobifunctional PEG crosslinker with Maleimide (HY-W007324) and amine. Mal-PEG3-NH2 TFA is a non-degradable (non-cleavable) PROTAC linker.
    Mal-PEG3-NH2 TFA
  • HY-138470
    Azido-PEG2-C6-Cl 2568146-55-2
    Azido-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C6-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-C6-Cl
  • HY-113931
    Aminooxy-PEG2-azide 1043426-13-6
    Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Aminooxy-PEG2-azide
  • HY-140676
    mPEG-amine (MW 2000) 80506-64-5 99.57%
    mPEG-amine (mPEG-NH2) (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    mPEG-amine (MW 2000)
  • HY-33366
    Boc-NH-PEG3-CH2COOH 462100-06-7
    Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Boc-NH-PEG3-CH2COOH
  • HY-W019798
    NH2-PEG8-acid 756526-04-2 ≥98.0%
    NH2-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG8-acid also is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG8-acid
  • HY-140177
    Amino-PEG12-acid 1415408-69-3 ≥98.0%
    Amino-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG12-acid
  • HY-141213
    Bromo-PEG2-alcohol 57641-66-4 98.98%
    Bromo-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG2-alcohol
  • HY-140761
    Azido-PEG16-NHS ester 99.91%
    Azido-PEG16-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG16-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG16-NHS ester
  • HY-135911
    Biotin-PEG2-OH 717119-80-7 ≥98.0%
    Biotin-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2-OH
  • HY-140698
    m-PEG-NHS ester (MW 5000) 92451-01-9
    m-PEG-NHS ester (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-NHS ester (MW 5000)
  • HY-141278
    Methyltetrazine-PEG4-maleimide 1802908-02-6 98.61%
    Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-PEG4-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Methyltetrazine-PEG4-maleimide
  • HY-133392
    Azido-PEG5-azide 356046-26-9 99.98%
    Azido-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-azide
  • HY-140988
    Mal-NH2 TFA 146474-00-2 99.32%
    Mal-NH2 (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-NH2 TFA
  • HY-129622A
    NH2-PEG5-C6-Cl hydrochloride 2241669-16-7 ≥98.0%
    NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG5-C6-Cl hydrochloride
  • HY-W055870
    Hydroxy-PEG1-(CH2)2-Boc 671802-00-9 99.96%
    Hydroxy-PEG1-(CH2)2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG1-(CH2)2-Boc
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.