2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140209
    Amino-PEG7-amine 332941-25-0 99.30%
    Amino-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG7-amine
  • HY-116899
    Nonaethylene glycol 3386-18-3 99.87%
    Nonaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Nonaethylene glycol
  • HY-140033
    Propargyl-PEG3-amine 932741-19-0 98.0%
    Propargyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-amine
  • HY-114670
    Propargyl-PEG4-amine 1013921-36-2 99.71%
    Propargyl-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-amine
  • HY-W051634
    Propargyl-PEG2-amine 944561-44-8 99.64%
    Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG2-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-amine
  • HY-W025896
    Boc-NH-PEG4 106984-09-2
    Boc-NH-PEG4 (PROTAC Linker 12) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG4
  • HY-40142
    1-N-Boc-3-hydroxyazetidine 141699-55-0 99.63%
    1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
    1-N-Boc-3-hydroxyazetidine
  • HY-W047688
    tert-Butyl (10-aminodecyl)carbamate 216961-61-4
    tert-Butyl (10-aminodecyl)carbamate (1-Boc-1,10-diaminodecane) can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. tert-Butyl (10-aminodecyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    tert-Butyl (10-aminodecyl)carbamate
  • HY-130474
    Azido-PEG6-NHS ester 2055014-64-5 98.0%
    Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-NHS ester
  • HY-W040134
    Mal-amido-PEG4-NHS ester 756525-99-2 99.24%
    Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG4-NHS ester
  • HY-120702
    N-Boc-PEG5-bromide 1392499-32-9 98.0%
    N-Boc-PEG5-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG5-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Boc-PEG5-bromide
  • HY-130830
    m-PEG24-NHS ester 2395839-96-8 99.66%
    m-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG24-NHS ester
  • HY-W007545
    NH2-PEG3 6338-55-2 99.87%
    NH2-PEG3 (PROTAC Linker 35) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. NH2-PEG3 (PROTAC Linker 35) can be used in the synthesis of the PROTAC (β-NF-JQ1).
    NH2-PEG3
  • HY-138382
    m-PEG4-PFP ester 2952895-31-5 ≥98.0%
    m-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG4-PFP ester
  • HY-40178
    NH2-C4-NH-Boc 68076-36-8 99.98%
    NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    NH2-C4-NH-Boc
  • HY-130442
    Mal-PEG2-acid 1374666-32-6 99.66%
    Mal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin (HY-128914) and its derivative cytotoxic molecule. Mal-PEG2-acid is also a PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG2-acid
  • HY-130346
    DBCO-PEG4-DBCO 2182601-68-7
    DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-DBCO
  • HY-W190796A
    Mal-PEG3-NH2 TFA 2830214-77-0 99.07%
    Mal-PEG3-NH2 TFA is a linear heterobifunctional PEG crosslinker with Maleimide (HY-W007324) and amine. Mal-PEG3-NH2 TFA is a non-degradable (non-cleavable) PROTAC linker.
    Mal-PEG3-NH2 TFA
  • HY-113931
    Aminooxy-PEG2-azide 1043426-13-6
    Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Aminooxy-PEG2-azide
  • HY-140217
    Azido-PEG10-amine 912849-73-1
    Azido-PEG10-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG10-amine
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.